What is obesity and why is it bad?
Obesity is a major problem in today's society, with more than 1 billion people in all parts of the world classed as obese cost the British health insurance system alone £ 1 billion annually. Obesity is an increase in fatty tissue, to the extent that it can cause a variety of negative effects on health. These problems include many physical and psychological, for example, emotional problems, including feelings of inferiority, low self-esteem, and often in children, and intimidation of classmates. Physical problems, including high blood pressure, heart disease and some cancers and diabetes type 2 (T2DM), which is when the body no longer responds to insulin and therefore can not control blood sugar levels. By 2025 300 million people are expected to suffer from diabetes associated with obesity, and this figure is twice what it was in 1998.
How to measure obesity?
There are many methods to measure body fat percentage, but the most common method is to use the body mass index (BMI), which measures the relationship between weight and length. Another measure or more than 30 puts you in the category of people suffering from obesity. For more information about testing to measure the body mass index, body mass index, your please click here. Body mass index may be the most popular method but has its disadvantages, for example. People who carry a lot of muscle will not receive the accurate measurement of body mass index because of the muscle is heavier than fat. Other measures are more complicated than fat, but still a body mass index is the most popular method used because it is very simple.
What drugs are used to combat obesity?
The first anti-obesity drug developed at the end of 1950. This was Phentermine, related to amphetamines. The drug worked by stimulating the release of catecholamines and therefore urges that 'fight or flight' response and loss of appetite. This became available in the market in early 1970 Phentermine hydrochloride. This medicine is now a controlled substance were also found a high degree of addiction, and therefore can not be taken only for short periods of time. This medication has also been found to affect the heart causing side effects such as high blood pressure and valve problems. Phentermine can also cause insomnia, so it can only be taken at certain times of the day.
Fenfluramine was another anti-obesity drugs that have worked to increase central serotonin levels and caused a sensation of fullness, and therefore loss of appetite. This drug was withdrawn in 1997 after reports of high blood pressure and other problems related to valves of the heart. How exactly these drugs cause loss of appetite are not known, probably due to a combination of factors. Fenfluramine was also used in combination with Phentermine and is called called 'Fen - Phen'.
And other anti-obesity drug Xenical is available. This drug acts peripherally as inhibits an enzyme involved in causing the breakdown of fat and fatty acids to excreted instead of digested. Side effects of this medication problems include bowel movement and the secretion of essential vitamins. The amount of weight loss by taking Xenical is different and that can only be taken for short periods of time. For more information about how to Xenical Xenical, please visit the main page by clicking here.
Therefore, there were 50 years of research into obesity, and after a very small number of drugs have been licensed. This highlights the complex system of neurons that control appetite. Current knowledge regarding the control of appetite and food consumption in all stems from the pioneering experiments carried out since many years, without which, it can be to discuss the obesity does not have occurred. These tests involve the establishment of the role of the hypothalamus regulate appetite and the role of peripheral signals in the signal energy levels. Please click on the link below to start a discussion on the current understanding of how to regulate appetite came.
Genetics and Obesity: genes are the bullet - but you have to press the trigger
Many of the genes thought to be involved in appetite and obesity, but very recently, in a gene called gene (F, on chromosome 16 was found to confer a predisposition to obesity (Frayling et al, 2007). It has been known for some time that genes play a role in obesity, but this study confirms this. it was reported that 16% of the population carry this gene, and if every individual is a copy of this gene by 70% are more prone to 3kg heavier than the average. This discovery confirms that obesity can stem not only from malnutrition and lack of exercise, but in fact, that genetics do not play a role. This study does not mean that this gene is solely responsible for obesity, there are likely to have many of the genes responsible. What does this study is to highlight the effects that can play genetics in the development of obesity and people discovered that this gene can do something about it, and take responsibility for his body, after all, you can change your lifestyle but you can not change your genes. to gain access to research behind this story, please see the key references.
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